The Holy See is the jurisdiction of the Catholic Church in Rome, and it is a sovereign entity recognized by international law. The Holy See is not a state, but it has diplomatic relations with many countries and is a permanent observer to various international organizations, including the United Nations. The Holy See is headed by the Pope, who is the Bishop of Rome and the leader of the worldwide Catholic Church. The Pope is assisted in the governance of the Church by the Roman Curia, which is a complex bureaucracy that includes various departments and offices responsible for different aspects of the Church's administration. The Holy See also has a number of embassies and other diplomatic missions around the world, and it is involved in various charitable and humanitarian initiatives.

Holy See maintains contact with 63 countries. The five most intense relations Holy See has are with: Israel with a score of 60 495 , Ireland with a score of 13 935 , Monaco with a score of 13 608 , United Kingdom with a score of 12 838 , and Germany with a score of 12 782 .

The top five closest relations from Holy See are: Palestine with a score of 9.72 , Israel with a score of 9.09 , United Kingdom with a score of 8.88 , China with a score of 8.18 , and United States with a score of 8.01 .

While, the top five strained relations from Holy See are: Ireland with a score of 0.77 , Algeria with a score of 3.02 , Bosnia and Herzegovina with a score of 3.24 , Ivory Coast with a score of 3.62 , and Turkey with a score of 3.62 .